Neuroendocrinology Letters Vol. 25 No.6, December 2004
نویسندگان
چکیده
AIM OF THE STUDY: The investigation of the influence of anti-opioid drug on hypophyseal and gonadal hormones secretion in case of Klinefelter syndrome. MATERIAL AND METHODS: The naloxone test (0,4 mg iv) was performed in 14 patients with Klinefelter syndrome aged from 19 to 32 and in 12 age matched control subjects with azoospermia and normal spermatogenesis in testicular histology. The plasma levels of FSH, LH, prolactin, testosterone and estradiol were established before and after 30, 60, 90 and 120 minutes respectively, following the drug administration. RESULTS: Basal FSH, prolactin and estradiol levels were significantly higher whereas basal testosterone was significantly lower in patients with Klinefelter syndrome than in the control group.After the naloxone administration the mean plasma prolactin level decreased significantly (p=0.01) in Klinefelter subjects. The respective diminution in control group was not significant. The levels of FSH and LH as well as testosterone and estradiol did not change during the naloxone test in both Klinefelter and control subjects. CONCLUSIONS: The naloxone administration in Klinefelter syndrome caused the decrease in plasma prolactin levels but did not affect the plasma levels of another hypophyseal and gonadal hormones. The opioid controlled gonadotropin secretion is altered in case of Klinefelter syndrome C L I N I C A L S T U D Y
منابع مشابه
Neuroendocrinology Letters Vol. 25 No.6, December 2004
OBJECTIVE: To examine the effect of ipamorelin (IPA), a novel pentapeptide with a strong growth hormone releasing potency, on insulin secretion from pancreatic tissue fragments of normal and diabetic rats. MATERIALS AND METHODS: Diabetes mellitus was induced by streptozotocin (60 mg kg–1). Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were r...
متن کاملNeuroendocrinology Letters Vol. 25 No.6, December 2004
OBJECTIVES: Relationship between melatonin and prolactin has been suggested on the basis of both experimental and clinical studies. However, there are scarce and controversial data concerning melatonin concentrations in hyperprolactinemic patients. Therefore, the aim of the present study was to evaluate the circadian rhythm of melatonin in female patients suffering from hyperprolactinemia. MATE...
متن کاملNeuroendocrinology Letters Vol. 25 No.6, December 2004
OBJECTIVES: The purpose of this study was to investigate whether melatonin levels in older cohorts within the ‘aged’ population were significantly lower than in younger ‘aged’ individuals and hence point to a possible confound in cross-sectional studies which group individuals over 55 in one category. SETTING AND DESIGN: Melatonin levels of 35 North Queensland residents over 55 years of age liv...
متن کاملNeuroendocrinology Letters Vol. 25 No.6, December 2004
OBJECTIVES : A novel evaluative approach was used to determine single unit activities of non-bursting intralaminar thalamic nuclei under neuropathic pain state following dorsal rhizotomy. SETTINGS AND DESIGN: Extensive dorsal rhizotomy at cervicothoracic level in rats was used as a model of central pain. After rhizotomy, rats were divided into two groups: rats without any signs of self-mutilati...
متن کامل